2024년 한국동물유전육종학회 동계워크숍
1. 행사명(주제)
- 행사명: 2024년 한국동물유전육종학회 동계워크숍
- 주제: Multi-Omics Systems Biology and Gene Networks Inference: Applications to Animal Breeding and Genetics (동물유전육종학에 적용 가능한 멀티오믹스 기반 시스템생물학 및 유전자 네트워크 분석 방법론)
2. 발표내용 및 강사
- Dr. Antonio Reverter, “Toni”
- 약력
- Senior Principal Research Scientist (Current): Animal Genomics Unit, CSIRO Agriculture and Food, 호주
- Researcher: Animal Genetics and Breeding Unit (AGBU), University of New England, 호주
- PhD in Statistics & Animal Science: Colorado State University, 미국
- 주요업적
- 분산성분추정: Method R(https://doi: 10.2527/1994.7292247x.)
- 유전자 네트워크 분석: Association weight matrix (https://doi.org/10.1073/pnas.1002044107)
- 약력
3. 날짜
- 날짜 : 2024. 1. 17.(수) 09:00 ∼ 1. 19.(금) 12:00
- 온라인접수(등록) : 2024년 1월 4일(목)까지
- 일정 : 1월 17일(수) 09:00 ~ 1월 19(금) 12:00
- 기념촬영 및 수료증 배부 : 1월 19일(금) 12:00
4. 장소
- 계룡스파텔(대전 유성구 온천로 81, 042-602-1410)
5. 등록신청 및 문의
-
- 전화번호 02-585-9307(한국동물유전육종학회 사무국)
- 이메일 ineejjyun@nate.com
- 신청양식 : 소속, 성명, 전화번호, 이메일, 숙박이용 유무
* 신청내용을 기재하여 메일로 접수하여 주시기 바랍니다.(일괄신청가능) - 예시
| 소속 | 성명 | 전화번호 | 이메일 | 숙박 | 결제방법 |
| 동물유전육종학회 | 홍유전 | 010-1234-5678 | gene@ksabng.org | O | 온라인카드 |
| ○○대학교 | 김육종 | 010-5678-1234 | blup@ksabng.org | X | 무통장입금 |
6. 등록비
- 30만원(아래의 2가지 방법 중 선택하셔서 등록비를 납부해 주시기 바랍니다.)
- 사전등록기간 : 2024년 1월 4일(목)까지
- 2024년도 워크숍은 사전등록을 원칙으로 하므로 현장등록은 받지 않을 예정입니다.
- 등록인원은 40명(선착순)이며 등록일정이 조기 마감 될 수 있습니다.
- 무통장입금 : NH은행(농협) 351-0962-3672-43 (예금주 : 사단법인 한국동물유전육종학회)
- 온라인 카드 결제(https://pay.docuhut.com/2024-ksabng-conference-workshop.html)
* 결제(카드/입금) 전 이메일로 등록신청 부탁드립니다. - 숙박비 및 식사 포함
- 교통비 별도
7. 준비물
- 노트북(필참) : 사전준비 사항은 이메일로 전달할 예정
8. 행사 세부일정
Multi-Omics Systems Biology and Gene Networks Inference: Applications to Animal Breeding and Genetics
DAY 1 – Wednesday 17 January 2024
- 9:30 – 10:30:PREAMBLE – GENERAL (OPEN) SEMINAR:
“How much mathematics does a biologists need and the promise of multi-omics – The experience of a veterinarian statistician.”
- 10:30 – 11:00:COURSE OUTLINE
- 11:00 – 11:15:Morning Break
- 11:15 – 12:30:REVIEW OF MOLECULAR CELL BIOLOGY AND ‘OMICS’ DATA
- Prokaryotes vs Eukaryotes
- Basic cell functions: Replication, Transcription, and Translation
- Organic compounds: Carbohydrates, Lipids, and Proteins
- The ABC of Metabolism
- Review of ‘Omics’ data: Genomics, Epigenomics, Transcriptomics, Proteomics, Metabolomics, Metagenomics/Microbiomics
- What is spatial omics?
- 12:30 – 13:30:Lunch Break
- 13:30 – 15:00:OVERVIEW OF GENOTYPE DATA ANALYSIS
- Essential Metrics: Minor allele frequency (MAF), Hardy-Weinberg Equilibrium (HWE), Heterozygosity (HET), Runs of Homozygosity (ROH), Linkage Disequilibrium (LD)
- GRM: Genomic Relationship Matrix
- GWAS: Genome-Wide Association Studies
- GBLUP: Genomic Best Linear Unbiased Predictions
- Genomic prediction accuracy and the LR Method
- 15:00 – 15:15:Afternoon Break
- 15:15 – 18:00:IN-CLASS HOMEWORK/PRACTICE #1
- Basic UNIX Commands and Toni’s AWK Scripts
- Introduction to GAUDI.f90 program
- Practice with multi-breed data from Porto-Neto et al. (2023): https://pubmed.ncbi.nlm.nih.gov/36701372/
- Phenotypes and Genotypes
- GRMs at various thresholds of MAF
- Breed-specific GRM
- PCA of the GRM
DAY 2 – Thursday 18 January 2024
- 9:00 – 10:30:INTRODUCTION TO TRANSCRIPTOMICS (RNA-SEQ) DATA ANALYSIS
- Data Preparation, Edits, Transformation and Normalization
- Differential expression and Functional categories of interest
- Gene Ontology (GO) and Functional Enrichment:
- UCSF Library: https://guides.ucsf.edu/bistats/pathenrich
- WebGestalt: https://www.webgestalt.org/option.php
- Cluster analysis and the PermutMatrix software
- 10:30 – 10:45:Morning Break
- 10:45 – 12:00:IN-CLASS HOMEWORK/PRACTICE #2
- PermutMatrix: http://www.atgc-montpellier.fr/permutmatrix/
- Bovine Data from Cánovas et al. (2014): https://pubmed.ncbi.nlm.nih.gov/25048735/
- Salmon Data from Mohamed et al. (2022): https://pubmed.ncbi.nlm.nih.gov/35650521/
- 12:00 – 13:00:Lunch Break
- 13:00 – 14:00:BEYOND DIFFERENTIAL EXPRESSION AND GENE CO-EXPRESSION NETWORKS
- The quest for causal mutations and eQTL (Expression Quantitative Trait Loci)
- Network theory metrics: Motifs, connectivity degree and clustering coefficient
- Algorithms for the inference of gene networks: Random vs Scale-Free networks
- 14:00 – 15:00:IN-CLASS HOMEWORK/PRACTICE #3
- Introduction to the Cytoscape software: https://cytoscape.org/
- Multi-tissue from Alexandre et al. (2019): https://pubmed.ncbi.nlm.nih.gov/30967894/
- 15:00 – 15:15:Afternoon Break
- 15:15 – 16:30: THE PCIT ALGORITHM AND RIF METRICS
- PCIT – Partial Correlation and Information Theory
- RIF – Regulatory Impact Factors
- 16:30 – 18:00:IN-CLASS HOMEWORK/PRACTICE #4
- Introduction to PCIT.f90 and RIF.f90 source codes.
- Bovine Data from Cánovas et al. (2014): https://pubmed.ncbi.nlm.nih.gov/25048735/
- Salmon Data from Mohamed et al. (2022): https://pubmed.ncbi.nlm.nih.gov/35650521/
DAY 3 – Friday 19 January 2024
- 9:00 – 10:30: POST-GWAS ANALYSES
- Meta-analysis of GWAS results:
- Lin and Zeng, 2010. Genet Epidemiol. 34:10.1002/gepi.20435.
- Cantor, Lange and Sinsheimer, 2010. Am J Hum Genet 86:6-22.
- Fang and Pausch 2019. BMC Genomics 20:695
- Bolormaa et al. 2014. PLoS Genet 10:e1004198.
- Gene Co-Association Networks: The AWM (Association Weight Matrix) algorithm
- Fortes et al. 2010. Proc Natl Acad Sci USA 107:13642-13647.
- Reverter and Fortes. 2013. Methods Mol Biol. 1019:437-447.
- Gene Co-Association Networks: The AWM (Association Weight Matrix) algorithm
- 10:30 – 10:45:Morning Break
- 10:45 – 11:45: RECENT APPLICATIONS TO LIVESTOCK
- New molecular phenotypes: ImmuneDEX
- GBLUP: Wagyu Feeder Check
- RIF-PCIT-AWM: Pig’s microbiome
- GWAS-RNA-Seq: Pig’s sperm quality
- GWAS Meta-Analysis: Beef production traits
- 11:45 – 12:00: RECAPITULATION, CONCLUDING REMARKS AND FAREWELL
9. 결재
- 온라인 카드 결제는 우리 학회의 홈페이지 운영사인 도큐헛(주)에서 제공해드립니다. PC와 모바일 기기에서 결제가 가능합니다.